Table 5.
Storage stability of the selected lyophilized NCs at room temperature.
| Month | Size (nm) | PDI | Drug Content (%) | ζ-Potential (mV) |
|---|---|---|---|---|
| DSN–PLX188 NCs | ||||
| 0 | 349.43 ± 5.75 | 0.24 ± 0.02 | 93.12 ± 0.57 | −25.17 ± 0.38 |
| 1 | 349.83 ± 5.22 | 0.21 ± 0.03 | 93.32 ± 0.30 | −24.80 ± 0.30 |
| 2 | 362.60 ± 7.74 | 0.25 ± 0.02 | 93.20 ± 0.55 | −23.63 ± 0.65 |
| 3 | 374.87 ± 3.11 * | 0.19 ± 0.01 | 92.83 ± 0.83 | −21.86 ± 0.75 * |
| DSN–PLX188–CS NCs | ||||
| 0 | 360.63 ± 7.07 | 0.21 ± 0.03 | 93.29 ± 0.58 | 40.43 ± 0.15 |
| 1 | 358.97 ± 6.27 | 0.22 ± 0.02 | 92.91 ± 0.51 | 39.63 ± 1.42 |
| 2 | 364.80 ± 4.49 | 0.25 ± 0.02 | 93.08 ± 0.74 | 39.17 ± 0.81 |
| 3 | 355.83 ± 7.86 | 0.19 ± 0.01 | 93.03 ± 1.21 | 39.60 ± 0.36 |
Data are presented as the mean ± SD. The statistical analysis was performed at p < 0.05. * indicates a significant difference vs. the corresponding initial measurements at zero time.