Table 2.
Characteristics of healthy subjects and patients with cirrhosis, mild-COVID-19, and ARDS-COVID-19.
| Patient Characteristics | Healthy Subjects (n = 10) |
Cirrhosis (n = 127) |
Mild-COVID (n = 9) |
ARDS-COVID (n = 11) |
p-Value |
|---|---|---|---|---|---|
| Sex, male/female (% male) | 6/4 (60.0%) | 83/44 (65.4%) | 2/7 (22.2%) | 6/5 (54.5%) | 0.075 |
| Age, years (IQR) | 30.2 (15.4) | 54.6 (15.9) | 57.1 (19.6) | 57.4 (20.5) | <0.001 |
| Angiotensin converting enzyme, U × L−1 (IQR) |
30.2 (39.2) | 48.6 (39.2) | 23.7 (16.3) | 25.4 (27.7) | <0.001 |
| Plasma renin concentration, µIU × mL−1 (IQR) |
22.2 (15.8) | 22.0 (103.9) | 11.1 (14.6) | 62.7 (107.1) | 0.050 |
| Plasma aldosterone concentration, pg × mL−1 (IQR) |
174.0 (161.0) | 109.5 (247.0) | 39.5 (78.0) | 49.0 (48.0) | <0.001 |
| D-dimer, µg × mL−1 (IQR) | 0.28 (0.15) | 0.62 (1.75) | 0.54 (0.58) | 2.94 (4.75) | <0.001 |
| Von Willebrand factor antigen, % (IQR) |
94.0 (44.0) | 268.0 (130.0) | 247.5 (73.0) | 420.0 (99.0) | <0.001 |
| Prothrombin fragment F1,2, pmol × L−1 (IQR) |
137.5 (181.0) | 282.0 (265.0) | 151.5 (252.0) | 429.0 (2687.0) | <0.001 |
| Plasminogen activator inhibitor, IU × mL−1 (IQR) |
1.41 (2.64) | 0.89 (2.02) | 0.58 (4.76) | 0.61 (5.02) | 0.135 |
| α-2 antiplasmin activity, % (IQR) | 104.5 (13.0) | 67.0 (24.0) | 110.0 (15.0) | 108.0 (27.0) | <0.001 |
| Plasminogen activity, % (IQR) | 96.0 (14.0) | 66.0 (21.0) | 100.0 (26.0) | 92.0 (46.0) | <0.001 |
| C-reactive protein, mg × dL−1 (IQR) | 0.08 (0.08) | 0.29 (0.51) | 0.50 (1.42) | 15.10 (14.69) | <0.001 |
| Interleukin-6, pg × mL−1 (IQR) | 1.58 (0.19) | 8.86 (11.09) | 7.66 (14.74) | 65.70 (357.90) | <0.001 |
Note: Bold font shows statistically significant differences between groups.