Table 3.
Assessment of independent determinants of plasma levels of ACE activity in cirrhotic patients by multiple linear regression analysis: (i) univariate analysis; and adjusted models (ii) including Von Willebrand factor antigen, (iii) prothrombin fragment F1,2; or (iv) α-2 antiplasmin activity. Bold font shows statistically significant differences between groups.
| (i) | (ii) | (iii) | (iv) | |||||
|---|---|---|---|---|---|---|---|---|
| B | p | aB | p | aB | p | aB | p | |
| Age, per 10 years | −2.49 | 0.267 | - | - | - | - | - | - |
| Sex (male) | 5.28 | 0.365 | - | - | - | - | - | - |
| MELD, points | 1.76 | 0.005 | 1.02 | 0.147 | 0.69 | 0.396 | 0.24 | 0.769 |
| HVPG, mmHg | 0.84 | 0.069 | −0.08 | 0.882 | 0.02 | 0.970 | −0.14 | 0.790 |
| Albumin, g × L−1 | −1.32 | 0.008 | −0.21 | 0.758 | −1.32 | 0.007 | 0.24 | 0.737 |
| Sodium, mmol × L−1 | −1.13 | 0.140 | - | - | - | - | - | - |
| Mean arterial pressure, mmHg | −0.09 | 0.605 | - | - | - | - | - | - |
| Von Willebrand factor antigen, % |
0.10 | 0.001 | 0.10 | 0.001 | - | - | - | - |
| Prothrombin fragment F1,2, pmol × L−1 | −0.03 | 0.027 | - | - | −0.03 | 0.023 | - | - |
| α-2 antiplasmin activity, % |
−0.62 | <0.001 | - | - | - | - | −0.58 | 0.006 |
| C-reactive protein, mg × dL−1 |
−1.87 | 0.551 | - | - | - | - | - | - |
| Interleukin-6, pg × mL−1 | 0.12 | 0.411 | - | - | - | - | - | - |