Table 1.

Inhibition of PgQC by tetrahydroimidazo[4,5-c]pyridines with alkyl and acyl modifications.

	R1	R2	R3	Ki [µM]
6a		-		no inhibition @ 10 µM
7a		H	H	0.909 ± 0.005
7b		H	H	6.470 ± 0.400
7c		-CH2OCH2-		1.755 ± 0.145
7d		CH3	-	3.080 ± 0.040
7e			-	no inhibition @ 10 µM
8a		H	H	0.435 ± 0.015
8b		H	H	1.680 ± 0.080
8c		H	H	1.750 ± 0.060
8d		H	H	1.575 ± 0.025