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. 2021 Nov 23;14(12):1206. doi: 10.3390/ph14121206

Table 2.

Inhibition of PgQC by N-benzoyltetrahydroimidazo[4,5-c]pyridines.

graphic file with name pharmaceuticals-14-01206-i007.jpg R1 R2 R3 Ki (µM)
8e H F H 0.879 ± 0.008
8f F H H 0.322 ± 0.006
8g F F F 0.904 ± 0.007
8h H Cl H 0.682 ± 0.025
8i Cl H H 0.174 ± 0.014
8j Cl Cl H 0.257 ± 0.016
8k Cl H Cl 0.100 ± 0.006
8l H OCH3 H 0.833 ± 0.049
8m OCH3 H H 0.335 ± 0.006
8n OCH3 OCH3 H 1.465 ± 0.304
8o OCH3 H OCH3 0.928 ± 0.021
8p -OCH2CH2O- H 1.335 ± 0.219
8q -OCH2O- H 0.560 ± 0.004
8r OnPr H H 0.780 ± 0.024
8s OCH3 F H 1.240 ± 0.113
8t OCH3 H Cl 0.087 ± 0.006
8u H Ph H 1.900 ± 0.071
8v Ph H H 0.547 ± 0.041
8w Ph H 0.126 ± 0.009