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. 2021 Nov 24;19(12):659. doi: 10.3390/md19120659

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Immunoblot demonstration (A,B) of myocardial Cx43 protein bands of functional P1 and P2 phosphorylated forms and the PO non-phosphorylated form in experimental rats. There is a tendency to decreased Cx43 levels in male WR and SHR rats from 6-week continuous light compared to rats in standard light conditions (C). Surprisingly, female WR responded to continuous light by increased Cx43 protein levels compared to rats in standard light conditions (D). Omacor^® ameliorated myocardial Cx43 protein levels and functional phosphorylated status in the WR and SHR males (E) and maintained in females (F). Values are the mean ± SD of 6 rats in each group. * p < 0.05 compared to WR; # p < 0.05 compared to SHR; ♣ p < 0.05 compared to SHR-L.