Figure 1.

Hsp90 structure and chaperone cycle. The Hsp90 homodimer goes through multiple conformational changes while folding client proteins. The phases when certain cochaperones, PPIase, HOP, CDC47, AHA1, and p23, bind are labeled by color. In the top right is the Cryo-EM structure of Hsp90 complexed with p23 in closed state 2 (PDB ID: 7L7J from [32]). The domains of Hsp90 are labeled NTD, MD, and CTD.