Table 2.

This table summarizes Hsp90 PTMs. The headers of the table are as follows: “Enzyme” is the enzyme that does the PTM. “PTM” is the type of modification. “Hsp90 Site” is this amino acid location of the modification. “Effect” describes experimental findings of the PTM.

Source	Enzyme	PTM	Hsp90 site	Effects	Pathology
[140]	Smyd2	Methylation	K616	methyl-hsp90 needed in proper sarcomere function	arrhythmia and myocardial stiffening
[141]		Nitrosylation	C589	sno-hsp90 stablizes TGF-$\beta$ receptor and promotes fibrosis	DCM, HCM
[142]	PKA	Phosphorylation	T89	reduces Hsp90-androgen receptor interaction	N/A
[143]	CK2	Phosphorylation	T36	inhibition of cdc37-hsp90 complex	N/A
[139]		SUMOylation	K191	recruits Aha1	N/A
[144]		Acetylation	K294	reduced client and cochaperone interactions	N/A