Figure 4.
Clinical validation of flavonoids on the mouse lung coinfection of S. aureus and P. aeruginosa: (A) Scheme of the pre-treatment and treatment of flavonoids on mouse lung coinfection. Briefly, mice were coinfected with S. aureus (1 × 109 CFUs) and P. aeruginosa (1 × 109 CFUs) and flavonoids were pre-treated or treated with infected mice for further determine the therapeutic effects. (B,C) Kaempferol had the better antibacterial effects on the lung coinfection of S. aureus and P. aeruginosa compared to quercetin on both pre-treatment (B) and treatment (C).