Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
18 was prepared using the procedure described in ref. 30. (a) 19 (1 eq.), 20 (1.5 eq), CuI (0.1 eq), (PPh3)2PdCl2 (0.2 eq), Et3N (0.25 M), 80 °C, 51%; (b) Pd(OH)2 (20% on carbon) (0.3 eq.), EtOH (0.1 M), H2 atm.; (c) CH2Cl2 (0.04 M), trifluoroacetic acid (TFA) (10% v/v); (d) 24 (1.1 eq), HATU (1.1 eq.), DIPEA (3 eq.), DMF (0.2 M), 32% 25 over three steps, 1% 10 over three steps.
