Table 1.

IC₅₀ values (µM) of intermedine (Im), intermedine N-oxide (ImNO), lycopsamine (La), lycopsamine N-oxide (LaNO), retrorsine (Re), retrorsine N-oxide (ReNO), senecionine (Sc) and senecionine N-oxide (ScNO) in primary mouse hepatocytes, HepD cells, H₂₂ cells and HepG2 cells.

	Cells	Hepatocytes	HepD	H22	HepG2
PA
Im		165.13 ± 15.70	239.39 ± 14.83	161.82 ± 21.91	189.11 ± 6.11
ImNO		170.61 ± 3.91	257.98 ± 20.47	143.79 ± 14.50	206.45 ± 7.31
La		140.28 ± 1.77	164.06 ± 15.53 **	192.72 ± 6.68	155.10 ± 14.86 *
LaNO		198.43 ± 30.23 *	178.79 ± 17.47	204.58 ± 5.51 *	181.76 ± 8.52
Re		138.68 ± 11.60	126.55 ± 7.98 ***	173.41 ± 4.88	157.85 ± 12.86
ReNO		146.26 ± 12.69	140.81 ± 7.58 **	238.48 ± 28.26 **	173.05 ± 4.31
Sc		245.52 ± 9.79 **	173.71 ± 6.88 *	215.13 ± 2.26 *	253.94 ± 20.51 **
ScNO		280.86 ± 12.83 ***	199.97 ± 9.02	158.38 ± 2.91	186.81 ± 6.68

Data are expressed as means ± S.D. of triplicate experiments performed independently. *: p < 0.05, **: p < 0.01 and ***: p < 0.001 compared with the IC₅₀ values of cells treated with Im.