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. 2021 Dec 20;14:9965–9976. doi: 10.2147/IJGM.S344448

Table 5.

Age–Period–Cohort (APC) Model Analysis Results of Colorectal Cancer Incidence and Mortality in China

Variables 95% CI
Effect Coefficient SE Z P LL UL
Age (incidence)
Age_20 −2.49 0.85 −2.92 0.00* −4.15 −0.82
Age_25 −1.75 0.50 −3.50 0.00* −2.73 −0.77
Age_30 −1.17 0.38 −3.09 0.00* −1.91 −0.43
Age_35 −0.80 0.34 −2.34 0.02* −1.47 −0.13
Age_40 −0.37 0.31 −1.22 0.22 −0.97 0.23
Age_45 −0.04 0.27 −0.14 0.89 −0.57 0.49
Age_50 0.34 0.23 1.49 0.14 −0.11 0.78
Age_55 0.60 0.18 3.30 0.00* 0.24 0.96
Age_60 0.85 0.14 6.19 0.00* 0.58 1.12
Age_65 1.01 0.10 10.28 0.00* 0.82 1.21
Age_70 1.12 0.08 13.92 0.00* 0.96 1.28
Age_75 1.09 0.10 11.10 0.00* 0.89 1.28
Age_80 0.98 0.14 7.02 0.00* 0.70 1.25
Age_85 0.63 0.19 3.30 0.00* 0.26 1.01
Period
Period_2005 −0.15 0.06 −2.63 0.01* −0.27 −0.04
Period_2010 0.02 0.03 0.65 0.51 −0.04 0.07
Period_2015 0.14 0.06 2.36 0.02* 0.02 0.25
Cohort
Cohort_1920 1.34 0.24 5.61 0.00* 0.87 1.80
Cohort_1925 1.25 0.18 6.94 0.00* 0.90 1.61
Cohort_1930 1.07 0.14 7.89 0.00* 0.80 1.33
Cohort_1935 0.88 0.11 8.22 0.00* 0.67 1.09
Cohort_1940 0.63 0.11 5.91 0.00* 0.42 0.83
Cohort_1945 0.37 0.13 2.80 0.01* 0.11 0.63
Cohort_1950 0.26 0.17 1.54 0.12 −0.07 0.60
Cohort_1955 0.14 0.22 0.64 0.52 −0.28 0.56
Cohort_1960 −0.06 0.26 −0.22 0.83 −0.57 0.45
Cohort_1965 −0.28 0.30 −0.92 0.36 −0.87 0.31
Cohort_1970 −0.47 0.34 −1.39 0.16 −1.14 0.19
Cohort_1975 −0.63 0.37 −1.71 0.09 −1.34 0.09
Cohort_1980 −0.92 0.40 −2.28 0.02* −1.71 −0.13
Cohort_1985 −1.08 0.47 −2.32 0.02* −1.99 −0.17
Cohort_1990 −1.12 0.69 −1.63 0.10 −2.47 0.23
Cohort_1995 −1.37 1.48 −0.93 0.35 −4.27 1.52
Age (mortality)
Age_20 −2.72 1.52 −1.79 0.07 −5.70 0.26
Age_25 −1.97 0.89 −2.20 0.03* −3.72 −0.22
Age_30 −1.41 0.69 −2.05 0.04* −2.76 −0.06
Age_35 −0.83 0.60 −1.37 0.17 −2.01 0.36
Age_40 −0.49 0.55 −0.89 0.37 −1.57 0.59
Age_45 −0.14 0.48 −0.29 0.78 −1.08 0.80
Age_50 0.15 0.40 0.38 0.70 −0.64 0.94
Age_55 0.38 0.32 1.18 0.24 −0.25 1.01
Age_60 0.71 0.24 3.00 0.00* 0.25 1.17
Age_65 0.94 0.16 5.73 0.00* 0.62 1.26
Age_70 1.17 0.13 9.20 0.00* 0.92 1.42
Age_75 1.37 0.16 8.51 0.00* 1.05 1.69
Age_80 1.44 0.24 6.09 0.00* 0.98 1.91
Age_85 1.38 0.33 4.21 0.00* 0.74 2.02
Period
Period_2005 −0.21 0.10 −2.02 0.04* −0.41 −0.01
Period_2010 0.04 0.04 1.01 0.31 −0.03 0.10
Period_2015 0.17 0.10 1.69 0.09 −0.03 0.37
Cohort
Cohort_1920 1.60 0.40 3.99 0.00* 0.81 2.38
Cohort_1925 1.46 0.31 4.78 0.00* 0.86 2.06
Cohort_1930 1.23 0.22 5.47 0.00* 0.79 1.66
Cohort_1935 0.99 0.17 5.92 0.00* 0.66 1.32
Cohort_1940 0.67 0.16 4.13 0.00* 0.35 0.99
Cohort_1945 0.40 0.21 1.90 0.06 −0.01 0.82
Cohort_1950 0.25 0.29 0.86 0.39 −0.32 0.81
Cohort_1955 0.08 0.37 0.20 0.84 −0.65 0.80
Cohort_1960 −0.10 0.45 −0.21 0.83 −0.99 0.79
Cohort_1965 −0.43 0.53 −0.81 0.42 −1.48 0.62
Cohort_1970 −0.65 0.60 −1.09 0.28 −1.83 0.52
Cohort_1975 −0.87 0.66 −1.33 0.19 −2.15 0.42
Cohort_1980 −1.06 0.71 −1.50 0.14 −2.46 0.33
Cohort_1985 −1.09 0.81 −1.34 0.18 −2.68 0.51
Cohort_1990 −1.25 1.23 −1.01 0.31 −3.65 1.16
Cohort_1995 −1.23 2.43 −0.51 0.61 −5.99 3.52

Notes: *Means P<0.05, and the difference is statistically significant. Incidence: variance=1.15; AIC=6.49; BIC=−43.74. Mortality: variance=1.05; AIC=5.68; BIC=−43.80.

Abbreviations: SE, standard error; LL, lower limit; UL, upper limit. AIC, Akaike Information Criterion; BIC, Bayesian Information Criterion.