Table 1.
METTL3 Regulates Adipocyte Differentiation Through Target Genes
| miRNA | Promoting Targeted Genes | Inhibitory Target Gene | Regulation of Target Genes on Adipocyte Differentiation |
|---|---|---|---|
| miR-21 | PTEN84 | Down regulate85 | |
| SMAD786 | Down regulate43 | ||
| miR-25 | BTG287 | Down regulate88 | |
| LATS247 | Up regulate50 | ||
| PTEN89 | Down regulate | ||
| FBXW790 | Down regulate49 | ||
| KLF444 | Up regulate44 | ||
| C/EBPα44 | Up regulate44 | ||
| miR-34a | AMPK55 | Down regulate91 | |
| SIRT153 | Down regulate92 | ||
| HDAC193 | Up regulate94 | ||
| mir-126 | VEGF95 | Down regulate65 | |
| IGF-196 | Up regulate97 | ||
| CRK98 | Up regulate62 | ||
| IRS-199 | Up regulate100 | ||
| AKT101 | Up regulate102 | ||
| PI3K103 | Up regulate78 | ||
| mir-143-3p | MAPK773 | Down regulate73 | |
| MAP3K768 | Up regulate74 | ||
| AKT71 | Up regulate | ||
| KLF570 | Up regulate76 | ||
| PI3K71 | Up regulate | ||
| EZH272 | Up regulate104 | ||
| mir-221/mir-222 | PTEN105 | Down regulate | |
| TIMP379 | Down regulate106 | ||
| AKT107 | Up regulate | ||
| p27Kip182 | Down regulate108 | ||
| mir-320 | ERK1/2109 | Down regulate110 | |
| PI3K111 | Up regulate | ||
| adipoR1112 | Up regulate113 |