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. 2021 Dec 17;2021:6370911. doi: 10.1155/2021/6370911

Figure 3.

Figure 3

IL-38 dampens LPS-induced activation of the NLRP3 inflammasome in macrophages. (a) Representative western blot image of indicated proteins in macrophages stimulated with LPS (1 μg/mL; 24 h) and/or IL-38 (200 ng/mL; 24 h). β-Actin protein was used for normalization. (b) Quantification of three independent experiments as shown in panel. (c) Representative immunofluorescence images of NLRP3 (green) of macrophages treated as in (a). Nuclei were stained with DAPI (blue). Magnification, ×600. Scale bar = 25 μm. ∗P < 0.05 and ∗∗P < 0.01vs. the normal control (NC) group. NC was PBS treatment. ##P < 0.01vs. the LPS group. n = 3 independent experiments.