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. 2021 Dec 1;23(1):50–61. doi: 10.1038/s41590-021-01084-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, Representative ICS flow cytometry plots measuring MIP1β and CD107a expression on T cell clones incubated with vaccinia virus encoding NP or peptide-loaded (3 nM peptide) antigen-presenting cells. b, Correlation plot between CD107a expression on T cell clones incubated with NP-expressing vaccinia virus and their respective EC₅₀ values (n = 14, R = −0.6176, P = 0.0212). c, Correlation plot between MIP1β production of T cell clones incubated with NP-expressing vaccinia virus and their respective EC₅₀ values (n = 14, R = −0.6879, P = 0.0082). d, Inhibition of SARS-CoV-2 virus replication (Victoria strain) by T cell clones with different EC₅₀ values and differing functional avidity (n = 11). e, Correlation plot between percentage of viral suppression by specific T cell clone and its corresponding EC₅₀ value (n = 11, R = −0.7699, P = 0.0075). Spearman’s rank correlation coefficient was used for correlation analysis with the two-tailed P value. Bar graph is presented as mean ± s.d.