Table 1.
Groups defined by shared TRBV gene usage and CDR3β sequence between bulk TCR sequencing from T cell clones and single-cell TCR sequencing from ex vivo T cells
| Group | CDR3β | TRBV | TRBJ | Functional avidity |
|---|---|---|---|---|
| 1 | CAISEPGTSGGAILDTQYF | TRBV10-3 | TRBJ2-3 | Low |
| 2 | CASGPATSAEQETQYF | TRBV12-5 | TRBJ2-5 | High |
| 3 | CASSILQGLGGSNQPQHF | TRBV19 | TRBJ1-5 | Low |
| 4 | CASSVLPGPPRGEQFF | TRBV2 | TRBJ2-1 | High |
| 5 | CSAQVGGNYNSPLHF | TRBV20-1 | TRBJ1-6 | High |
| 6 | CATSDLVTSGDEQFF | TRBV24-1 | TRBJ2-1 | Low |
| 7 | CASSGLTSLADTQYF | TRBV25-1 | TRBJ2-3 | High |
| 8 | CASSLITGGAKNIQYF | TRBV27 | TRBJ2-4 | Low |
| 9 | CASSPIAGGRKNIQYF | TRBV27 | TRBJ2-4 | Low |
| 10 | CASSPLTGSAERKETQYF | TRBV27 | TRBJ2-5 | High |
| 11 | CASSPLVGERFRKETQYF | TRBV27 | TRBJ2-5 | Low |
| 12 | CASSSLLAGGFYEQFF | TRBV27 | TRBJ2-1 | Low |
| 13 | CASSPIETAKNIQYF | TRBV28 | TRBJ2-4 | Low |
| 14 | CASSSITTTGAKDGYTF | TRBV28 | TRBJ1-2 | High |
| 15 | CASSLAGAEAFF | TRBV5-1 | TRBJ1-1 | High |
| 16 | CASSLAGGPLHEQFF | TRBV5-1 | TRBJ2-1 | Low |
| 17 | CASSSYPGLAPVQETQYF | TRBV5-1 | TRBJ2-5 | High |
| 18 | CASSYLPAGSSYNSPLHF | TRBV6-3 | TRBJ1-6 | High |