Table 3.
Prediction of effects of the mutation on different biological pathways.
| Protein Name | Mutation | Effects |
|---|---|---|
| Membrane Glycoprotein | H125Y | Altered Transmembrane protein |
| Altered Ordered interface | ||
| ORF8 | W45L | Altered Ordered interface |
| Altered Disordered interface | ||
| Altered DNA binding | ||
| Altered Transmembrane protein | ||
| ORF1A | T2408I | Altered Transmembrane protein |
| Gain of strand | ||
| Loss of Disulfide linkage at C2404 | ||
| Gain of N-linked glycosylation at N2405 | ||
| Loss of Catalytic site at C2404 | ||
| Loss of GPI-anchor amidation at N2405 | ||
| P2965L | Altered Transmembrane protein | |
| Altered Ordered interface | ||
| Loss of Relative solvent accessibility | ||
| Altered Metal binding | ||
| P3447S | Altered Transmembrane protein | |
| Altered Ordered interface | ||
| Loss of Allosteric Site at Y3445 | ||
| Gain of Strand | ||
| Loss of Relative solvent accessibility | ||
| Gain of Proteolytic cleavage at D3450 | ||
| Loss of Pyrrolidone carboxylic acid at Q3452 | ||
| Gain of Sulfation at Y3445 | ||
| ORF1AB | L3606 | Loss of Helix |
| Gain of Loop | ||
| Altered Ordered interface | ||
| Gain of Sulfation at Y3607 | ||
| Gain of Strand |