Table 5.

Meaningful change thresholds for WI-NRS (phase 3 cohort)

Criteria	N	Mean WI-NRS change scorea (SD)	Mean % change from baseline	Effect size (Cohen’s d)
Primary anchor-based approach
PGI-C minimally improved	198	− 1.85 (1.73)	− 25.73	1.09
Secondary anchor-based approach
PGI-C much improved	209	− 3.54 (2.08)	− 51.02	2.04
PGI-C minimally or much improved	407	− 2.72 (2.09)	− 38.72	1.48

PGI-C, Patient global impression of change; SD, standard deviation; WI-NRS, Worst Itching Intensity Numerical Rating Scale

^aChange from baseline to end of treatment