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. 2021 Dec 24;11:24435. doi: 10.1038/s41598-021-04018-9

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Metastatic outcomes of NSG mice bearing OS cell line xenografts. (a–d) Kaplan–Meier survival curves for mice based on timing of amputation following injection of MG63.3 (a), MNNG (b), Hu09-H3 (c), K7M2 (d). (e) Mantel–Cox identified significant differences in the survival curves of mice bearing MNNG, Hu09-H3, and K7M2 xenografts. Comparisons by amputation time point are included in the underlying tables. For multiple comparisons between timepoints within each cell line, a Bonferroni-corrected threshold for significance of < 0.0083 was used.