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. 2021 Dec 24;11:24413. doi: 10.1038/s41598-021-03993-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Protein–protein interaction (PPI) network of differentially expressed mRNAs (DEmRNAs) and hub genes in three brain regions. Blue nodes show the interaction among DEmRNAs in the PPI network in (a) hippocampus (HPC), (b) Brodmann area 46 (BA46), and (c) striatum (STR) regions. Hub genes in (d) HPC, (e) BA46, and (f) STR regions identified from the PPI network. Red, orange, and yellow nodes represent the hub genes with strong, moderate, and weak connections, respectively. This figure was generated using Cytoscape version 3.8.0 (https://cytoscape.org/)³⁹.