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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Addict Biol. 2021 Jun 25;27(1):e13075. doi: 10.1111/adb.13075

FIGURE 1.

FIGURE 1

Nicotine self-administration in rats under different access conditions. (A) Experimental timeline. Two groups (saline/nicotine) of rats underwent self-administration training for 2 weeks (acquisition phase, 1 h/day). Then, nicotine group was divided into two subgroups, that is, short-access group (Nic-ShA, 1 h/day) and long-access group (Nic-LA, 21 h/day). (B) Nicotine groups showed increased infusions compared with saline group during the acquisition phase. There was no difference between Nic-ShA group and Nic-LA group during this period. During the maintain phase, Nic-LA group showed increased total infusions compared with Nic-ShA group. Data are expressed as mean ± standard error of the mean (SEM); *p < 0.05, compared with saline; #p < 0.05, compared with Nic-ShA group. Saline: n = 18, Nic-ShA: n = 16, Nic-LA: n = 18