Table 5.
Mortality Odds Ratios Adjusted for Sex, RAI, OSS, Case Status, and PASC with Sex*PASC Interaction Term or PASC Subgroup Analyses
| 30-day | 90-day | 180-day | ||||
|---|---|---|---|---|---|---|
| Adjusted OR (95% CI) |
P value | Adjusted OR (95% CI) |
P value | Adjusted OR (95% CI) |
P value | |
| Sex*PASC Interaction Term Analysis (n=82,269) | ||||||
| Male (Ref = Female) | 0.98 (0.85–1.14) | .82 | 1.00 (0.89–1.13) | .99 | 1.00 (0.90–1.11) | .997 |
| RAI (Ref = Normal 21–29) | ||||||
| Robust (≤20) | 0.20 (0.17–0.24) | <.001 | 0.19 (0.17–0.22) | <.001 | 0.19 (0.17–0.22) | <.001 |
| Frail (30–39) | 2.39 (2.08–2.75) | <.001 | 2.80 (2.50–3.15) | <.001 | 3.05 (2.75–3.37) | <.001 |
| Very frail (≥40) | 4.02 (3.17–5.10) | <.001 | 4.88 (3.96–6.01) | <.001 | 5.52 (4.55–6.69) | <.001 |
| Expanded OSS (Ref = OSS1) | ||||||
| OSS2 | 1.90 (0.99–3.64) | .053 | 1.55 (0.97–2.47) | .07 | 1.72 (1.14–2.60) | .009 |
| OSS3 | 3.53 (1.87–6.69) | <.001 | 2.64 (1.67–4.18) | <.001 | 2.67 (1.78–4.00) | <.001 |
| OSS4 | 5.48 (2.88–10.43) | <.001 | 4.18 (2.63–6.65) | <.001 | 4.27 (2.83–6.42) | <.001 |
| OSS5 | 15.11 (7.65–29.81) | <.001 | 9.57 (5.79–15.83) | <.001 | 11.16 (7.20–17.31) | <.001 |
| Urgent/Emergent (Ref = elective) |
5.56 (4.78–6.48) | <.001 | 4.80 (4.27–5.41) | <.001 | 3.90 (3.54–4.30) | <.001 |
| PASC | 6.31 (5.19–7.67) | <.001 | 5.42 (4.56–6.45) | <.001 | 4.80 (4.08–5.65) | <.001 |
| Males*PASC | 0.78 (0.61–1.01) | .055 | 0.76 (0.60–0.95) | .02 | 0.73 (0.59–0.91) | .004 |
| Model C-Statistic | 0.91 | 0.90 | 0.88 | |||
| Subgroup Analyses | ||||||
| PASC subgroup (n=3,492) | ||||||
| Male (Ref = Female) | 0.80 (0.65–0.98) | .03 | 0.80 (0.66–0.96) | .02 | 0.78 (0.65–0.94) | .007 |
| RAI (Ref = Normal 21–29) | ||||||
| Robust (≤20) | 0.28 (0.21–0.36) | <.001 | 0.27 (0.21–0.34) | <.001 | 0.27 (0.22–0.35) | <.001 |
| Frail (30–39) | 1.87 (1.47–2.38) | <.001 | 2.29 (1.83–2.87) | <.001 | 2.32 (1.87–2.89) | <.001 |
| Very frail (≥40) | 2.69 (1.88–3.85) | <.001 | 3.06 (2.16–4.33) | <.001 | 3.38 (2.39–4.77) | <.001 |
| Expanded OSS (Ref = OSS1) | ||||||
| OSS2 | 2.89 (0.88–9.44) | .08 | 2.38 (0.93–6.09) | .07 | 2.98 (1.17–7.58) | .02 |
| OSS3 | 5.90 (1.84–18.94) | .003 | 4.51 (1.80–11.34) | .001 | 5.36 (2.14–13.45) | <.001 |
| OSS4 | 7.85 (2.44–25.26) | .001 | 6.73 (2.67–16.95) | <.001 | 7.76 (3.08–19.53) | <.001 |
| OSS5 | 7.70 (1.75–33.84) | .007 | 11.11 (3.38–36.57) | <.001 | 12.62 (3.89–40.99) | <.001 |
| Urgent/Emergent (Ref = elective) |
4.02 (2.48–6.50) | <.001 | 3.21 (2.18–4.74) | <.001 | 2.64 (1.87–3.73) | <.001 |
| Model C-Statistic | 0.76 | 0.77 | 0.77 | |||
| No PASC subgroup (n=78,777) | ||||||
| Male (Ref = Female) | 0.95 (0.82–1.11) | .53 | 0.98 (0.87–1.10) | .72 | 0.98 (0.89–1.09) | .69 |
| RAI (Ref = Normal 21–29) | ||||||
| Robust (≤20) | 0.17 (0.14–0.22) | <.001 | 0.17 (0.14–0.20) | <.001 | 0.17 (0.15–0.20) | <.001 |
| Frail (30–39) | 2.67 (2.24–3.17) | <.001 | 2.99 (2.61–3.43) | <.001 | 3.26 (2.90–3.66) | <.001 |
| Very frail (≥40) | 5.37 (3.99–7.24) | <.001 | 6.17 (4.83–7.88) | <.001 | 6.71 (5.38–8.37) | <.001 |
| Expanded OSS (Ref = OSS1) | ||||||
| OSS2 | 1.54 (0.72–3.33) | .27 | 1.31 (0.77–2.24) | .32 | 1.46 (0.93–2.30) | .10 |
| OSS3 | 2.70 (1.27–5.74) | .01 | 2.14 (1.27–3.60) | .004 | 2.15 (1.40–3.35) | .001 |
| OSS4 | 4.52 (2.10–9.70) | <.001 | 3.39 (1.99–5.77) | <.001 | 3.47 (2.21–5.46) | <.001 |
| OSS5 | 13.22 (6.01–29.10) | <.001 | 8.01 (4.57–14.06) | <.001 | 9.39 (5.83–15.11) | <.001 |
| Urgent/Emergent (Ref = elective) |
5.61 (4.77–6.59) | <.001 | 4.86 (4.29–5.51) | <.001 | 3.95 (3.56–4.37) | <.001 |
| Model C-Statistic | 0.88 | 0.87 | 0.86 | |||
Abbreviations: OR, Odds Ratio; OSS, Operative Stress Score; PASC, Preoperative Acute Serious Conditions; RAI, Risk Analysis Index; Ref, reference
Logistic regression analyses