Figure 1. Differences in plasma KIM-1 by histopathologic lesion.
Boxplots show differences between grades of adjudicated histopathologic lesions and plasma KIM-1 on a log scale. Boxplots show median and interquartile range (IQR) of plasma KIM-1 measured using a monoclonal detection antibody. Whiskers represent the IQR of the lower and upper quartile (25th and 75th percentile, respectively). P-values obtained from Wilcoxon or Kruskal-Wallis tests: p<0.001 for interstitial fibrosis/tubular atrophy, acute tubular injury, inflammation in the fibrosed and non-fibrosed interstitium, global glomerulosclerosis, mesangial expansion, arterial and arteriolar sclerosis; p=0.7 for glomerular inflammation; and p=0.4 for segmental sclerosis. 3 individuals had KIM-1 levels below the lower limit of quantification (LLOQ) which were imputed as LLOQ/2. Data on histopathologic lesion scores were missing for n=7 (global glomerulosclerosis), n=13 (segmental sclerosis), n=10 (interstitial fibrosis/tubular atrophy), n=12 (acute tubular injury), n=12 (inflammation in the non-fibrosed interstitium), n=10 (inflammation in the fibrosed interstitium), n=14 (mesangial expansion), n=16 (arterial sclerosis), and n=12 (arteriolar sclerosis).