Table 1. Potential roles for cPINK1 in mediating cellular proteostasis.

Proteostasis activity	Mechanism	Model system	References
Transcription	cPINK1 nuclear localisation promoted by monoubiquitination; implicated in phosphorylation of transcriptional regulators	Overexpressed ΔM104PINK1-EGFP in HeLa, HEK293T, SHSY5Y; siRNA PINK1 knockdown in HEK293	[22,23]
Translation	cPINK1-induced phosphorylation at Ser398 of the translation elongation factor eEF1A1	Overexpressed tagged cPINK1 in AD293	[21]
Trafficking	Trafficking of mitochondria, including within dendrites and axons, via interaction of cPINK1 with Miro/Milton or PKA	Expression of ∆MTS-Pink1 in HEK293-FT, COS7; overexpression of PINK1 in SHSY5Y, PINK1−/− primary cortical neurons; Drosophila	[24–26]
Aggregation	Direct K-48 ubiquitinated proteins to aggresomes via cPINK1-mediated phosphorylation of SQSTM1	Overexpressed tagged cPINK1 in AD293	[27]
Degradation	Sensor of proteasome capacity via cPINK1 accumulation; enhances autophagy during proteasome inhibition	MG132 proteasome inhibition	[23,27]
	Promotes α-syn degradation through autophagy via direct interaction with cPINK1 KD	Overexpression of truncated PINK1 variants in HEK293T	[28]