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. 2021 Dec 25;21:706. doi: 10.1186/s12935-021-02411-y

Fig. 4.

Fig. 4

Cordycepin increases osteosarcoma cell sensitivity to cisplatin by activating the AMPK signaling pathway and suppressing the AKT signaling pathway. a, b Western blotting analysis showing the protein expression levels of p-AMPK, p-AKT, p-mTOR, and p-p70S6K in U2OS and 143B osteosarcoma cells following a treatment with cordycepin (200 µM), cisplatin (1 µM), or their combination for 48 h