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. 2021 Dec 24;19:449. doi: 10.1186/s12951-021-01202-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — Anti-tumor effects of cocktail therapy based on M@P-PDR “Nano-targeted cells”. A Digital photos of 4T1 tumors on both sides in vivo and ex vivo on day 27 after different treatments. B Growth curves of the primary tumors (1st) and C the distant tumors (2nd) in different groups (n = 5, t-test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). D H&E staining, TUNEL staining and HSP70 staining images of the primary tumor (1st) excised at day 3 after different treatments, and PCNA staining images of the distant tumor (2nd) excised at day 9 after different treatments