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. 2021 Dec 24;19:449. doi: 10.1186/s12951-021-01202-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Degree of in vivo DCs maturation and polarization of TAMs based on M@P-PDR “Nano-targeted cells”. A Flow cytometric analysis of DCs maturation in primary tumors (1st) of mice in different treatment groups. and B the corresponding quantification of DCs maturation (n = 3). C Flow cytometric analysis of M2-TAMs (CD206⁺ F4/80⁺ CD11b⁺) in primary tumors (1st) and D the corresponding quantification of M2-TAMs (n = 3). E Flow cytometric analysis of M1-TAMs (CD80⁺ F4/80⁺ CD11b⁺) in primary tumors (1st) and F the corresponding quantification of M1-TAMs (n = 3, t-test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)