Fig. 3.

Somatic mutations in paired primary lung tumor tissue and CSF samples. A Genomic profiles of primary lung lesions (n = 11). Different colors denote different mutation types. B Genomic profiles of CSF cfDNA compared with those of primary lesions (n = 9). Two gray empty columns were the two patients who had insufficient cell-free DNA from CSF. Different colors denote whether mutations detected in CSF match with those in the paired primary lung tumor tissue (match), or were lung tumor tissue-specific or CSF-specific. TP53 loss of heterozygosity (LOH) status is indicated at the bottom of the Oncoprint. The top bars summarize the number of mutations detected from each patient. The left side of the oncoprint indicates the percentage of patients with mutations in the genes indicated on the right side. The side bars summarize the total number of mutations detected and the distribution of mutation types per gene. C Percentage and number of mutations in paired primary lung lesion and CSF samples for the indicated mutation types. CSF, cerebrospinal fluid; Lung-specific, mutations only detected in lung primary lung lesion; match, positive in the DNA of both the primary lung lesion and CSF; CSF-specific, mutations only detected in CSF; CNVs copy number variations, SNVs single-nucleotide variations; indel insertion-deletion variations