Fig. 5.

Extrapolation of stroke volume results into different timeframes. A Bar plot representing the CSF stroke volume exchanged between the intracranial and spinal space over one cardiac cycle in supine and upright position. B Extrapolation of resulting CSF volume exchanged per hour in both body orientations. C Extrapolation of cumulative CSF exchanged per day of supine and upright orientations in two scenarios with the first one consisting of 10 h in the supine position and 14 h in the upright position that showed significant greater (~ 7.5%) CSF volume exchanged than what obtained in the second scenario (5 h in supine and 19 h in upright position; **** = p < 0.0001)