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. 2021 Dec 24;18:61. doi: 10.1186/s12987-021-00296-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Summary of CSF hydrodynamic changes following shift from upright to supine body position. CSF peak velocities (arrow) and CSF volume displaced (bar) are distinguished in diastole and systole to highlight their caudo-cranial (blue) and cranio-caudal (red) directionality. Together with CSF phase duration (purple bar), all measurements are here represented in proportion to their absolute values. Percentage changes are reported with respect to upright measurements. Note that during diastole CSF peak velocity in supine is ~ 84% greater than what was measured in upright position whilst the diastolic duration is unchanged. However, during systole, the CSF peak velocity does not significantly change between positions whilst a ~ 36% increase is observed in supine systolic duration compared to upright. These differences lead to a greater CSF volume being displaced in supine compared to upright both cranially during diastole (+ 63%) and caudally during systole (+ 47%)