Table 2. Cox analysis of HMMR on OS and PFS in LUAD patients.

Parameter	Univariate Cox analysis			Multivariate Cox analysis
	HR	95% CI	P	HR	95% CI	P
TCGA (OS)
HMMR	1.550	[1.273–1.887]	<0.001	1.606	[1.317–1.959]	<0.001
Age	0.995	[0.976–1.014]	0.601	0.994	[0.975–1.013]	0.523
Gender	0.873	[0.592–1.288]	0.494	0.842	[0.568–1.248]	0.391
Stage	0.961	[0.782–1.182]	0.707	0.655	[0.372–1.153]	0.142
T classification	1.166	[0.915–1.485]	0.215	1.452	[1.068–1.973]	0.017
M classification	0.899	[0.416–1.944]	0.787	1.693	[0.452–6.342]	0.434
N classification	1.009	[0.771–1.319]	0.950	1.277	[0.761–2.143]	0.355
TCGA (PFS)
HMMR	1.627	[1.315–2.014]	<0.001	1.693	[1.368–2.094]	<0.001
Age	0.992	[0.973–1.012]	0.429	0.993	[0.973–1.013]	0.491
Gender	0.825	[0.557–1.221]	0.336	0.800	[0.536–1.194]	0.274
Stage	0.870	[0.703–1.075]	0.197	0.641	[0.359–1.146]	0.134
T classification	1.075	[0.832–1.389]	0.581	1.371	[0.978–1.921]	0.067
M classification	0.610	[0.247–1.508]	0.285	1.556	[0.347–6.972]	0.564
N classification	0.910	[0.700–1.185]	0.485	1.163	[0.696–1.945]	0.565
GSE68465 (OS)
HMMR	1.001	[1.000–1.002]	0.002	1.001	[1.000–1.002]	0.045
Gender	1.427	[1.101–1.849]	0.007	1.265	[0.971–1.648]	0.081
Age	1.027	[1.013–1.040]	<0.001	1.029	[1.015–1.043]	<0.001
Grade	1.135	[0.934–1.379]	0.204	0.960	[0.769–1.199]	0.719
N classification	2.012	[1.712–2.365]	<0.001	1.982	[1.683–2.335]	<0.001
T classification	1.665	[1.387–1.998]	<0.001	1.423	[1.174–1.725]	<0.001
GSE68465 (PFS)
HMMR	1.002	[1.001–1.003]	0.001	1.001	[1.000–1.003]	0.012
Gender	1.224	[0.872–1.718]	0.243	1.230	[0.871–1.736]	0.240
Age	1.010	[0.991–1.030]	0.305	1.017	[0.998–1.037]	0.085
grade	1.492	[1.125–1.979]	0.006	1.208	[0.892–1.634]	0.222
N classification	1.559	[1.257–1.934]	<0.001	1.570	[1.251–1.971]	<0.001
T classification	1.498	[1.175–1.909]	0.001	1.253	[0.961–1.635]	0.096

Note:

LUAD, lung adenocarcinoma; HR, hazard ratio; CI, confidence interval; P, p-value; OS, overall survival; PFS, progression-free survival.

The bold entries indicated the statistical significance (p-value<0.05).