Skip to main content
. 2021 Dec 25;11:220. doi: 10.1186/s13578-021-00732-z

Fig. 9.

Fig. 9

Proposed Model of Exosomal Function During RVFV Infection. EXi-RVFV released by infected cells travel to local and distant target naïve cells. Following entry, viral RNA genome carried by EXi-RVFV are released first, and specific viral RNA sequence(s) that form appropriate dsRNA panhandle structures induce RIG-I. The activation of RIG-I leads to induction of IFN-B that is subsequently released to elicit both autocrine and paracrine IFN responses that involves activation of autophagy. Increased autophagy leads to encapsulation of virus particles that could reach and enter the cell at a later stage, eliminating them through autolysosomes to result in a significant decrease in viral replication, and therefore propagation