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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Environ Int. 2021 Oct 28;158:106955. doi: 10.1016/j.envint.2021.106955

Table 4.

The top three DMPs associated with one IQR increase in PM2.5 and its PEs if they are located in the genes’ promoter in the site-by-site analyses.

Sources Particles CpG UCSC gene a Chr a Position p-value Difference in DNAm b
Motor vehicles BC cg24899205 TXNRD2 22 19,929,184 0.00 × 10−16 0.47
Cu cg12298562 RBP4 10 95,361,132 0.00 × 10−16 −1.68
Cu cg24912904 ACTN3 11 66,314,217 0.00 × 10−16 −0.97
Zn cg01910869 EDNRB 13 78,493,182 0.00 × 10−16 0.75
Oil combustion Ni cg19821536 OR6B3 2 24,098,376 1.33 × 10−12 −1.71
Power plants S cg22056044 TM9SF3 10 98,347,055 0.00 × 10−16 −2.32

Note: BC, black carbon; Cu, copper; Zn, zinc; Ni, nickel; S, sulfur.

a

The University of California Santa Cruz UCSC database (GRCh37/hg19)

b

Difference in DNAm level (% 5-mC) per one IQR increase in particles