Table 3.
Multivariable Linear Regression Analysis of Association Between Omentin-1 Gene Val109Asp Polymorphism and Risk of KOA Stratified by BMI
| Genotypes | BMI (kg/m2) | KOA (n=383) | NC (n=460) | Unadjusted Odds Ratios (95% CI) | p-value | Adjusted Odds Ratios (95% CI) | p-valuea |
|---|---|---|---|---|---|---|---|
| Asp/Asp | <25 | 71 | 137 | 1.000 (Reference) | – | 1.000 (Reference) | – |
| Val/Asp+Val/Val | <25 | 35 | 108 | 1.146 (0.502–3.972) | 0.698 | 1.125 (0.496–4.183) | 0.711 |
| Asp/Asp | ≥25 | 175 | 125 | 2.952 (1.264–6.104) | 0.029 | 2.564 (1.085–5.317) | 0.033 |
| Val/Asp+Val/Val | ≥25 | 102 | 90 | 1.583 (1.097–7.314) | 0.037 | 1.416 (1.018–7.072) | 0.042 |
Note: aAdjusted for age, gender, BMI, WHR, TCH, TG, lifestyle characteristics.
Abbreviations: KOA, knee osteoarthritis; NC, normal control; BMI, body mass index; WHR, weight hip ratio; TCH, total cholesterol; TG, triglyceride.