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. Author manuscript; available in PMC: 2021 Dec 26.
Published in final edited form as: Behav Brain Res. 2020 Jun 16;393:112771. doi: 10.1016/j.bbr.2020.112771

Figure 5. Experiment 2: Hippocampal Fos – ir acquisition related activation.

Figure 5.

Experiment 2: Mean percent change (from homecage subjects) in the number of dorsal hippocampal Fos – ir cells in response to context or context fear acquisition in males and females plotted across context exposure times. (A,C,E,F) Fos – ir activation in shocked and non-shocked groups. (B,D) CA1 proximal and distal of males and females were oppositely impacted by footshock exposure. Fold change in Fos-ir to footshock revealed significant sex differences (*p<.05) in CA1 proximal (B) and distal (D) regions of dorsal hippocampus. (E) No significant interactions in CA3 region were identified. (G) DG revealed a significant PSI x Condition interaction (p <.01). * denotes significant difference in across PSI in non-shocked groups (p<.05). n=85; 3–6 animals per group.