Comparison 1. Propionyl‐L‐carnitine versus placebo or control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Absolute claudication distance (MWD + PWT)	9	1121	Mean Difference (IV, Fixed, 95% CI)	50.86 [50.34, 51.38]
1.2 ACD (odds ratio)	9	1121	Mean Difference (IV, Fixed, 95% CI)	0.26 [0.23, 0.28]
1.3 Maximal walking distance (MWD)	6	692	Mean Difference (IV, Fixed, 95% CI)	50.43 [49.91, 50.96]
1.4 Peak walking time (PWT)	3	429	Mean Difference (IV, Fixed, 95% CI)	84.04 [79.57, 88.51]
1.5 ACD without Brevetti 1995 (sensitivity analysis)	8	907	Mean Difference (IV, Fixed, 95% CI)	55.90 [54.85, 56.95]
1.6 Initial claudication distance (PFWD + COT)	9	1151	Mean Difference (IV, Fixed, 95% CI)	32.98 [32.60, 33.37]
1.7 ICD (odds ratio)	9	1151	Mean Difference (IV, Fixed, 95% CI)	0.31 [0.28, 0.34]
1.7.1 Mixed group of diabetic and non‐diabetic patients	7	1058	Mean Difference (IV, Fixed, 95% CI)	0.29 [0.26, 0.32]
1.7.2 Diabetic patients only	2	93	Mean Difference (IV, Fixed, 95% CI)	0.47 [0.39, 0.56]
1.8 Pain‐free walking distance (PFWD)	6	722	Mean Difference (IV, Fixed, 95% CI)	33.19 [32.80, 33.58]
1.9 Claudication onset time (COT)	3	429	Mean Difference (IV, Fixed, 95% CI)	27.76 [25.05, 30.48]
1.10 ICD without Brevetti 1995 (sensitivity analysis)	8	937	Mean Difference (IV, Fixed, 95% CI)	39.24 [38.52, 39.96]
1.11 Quality of life (QoL)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.12 Ankle brachial index (ABI)	4	369	Mean Difference (IV, Fixed, 95% CI)	0.09 [0.08, 0.09]