Greco 1992.

Study characteristics
Methods	Randomized controlled double‐blind trial
Participants	20 diabetic patients with intermittent claudication minimum 1 year, ABI < 0.75, MWD from 100 to 500 m, and < 20% variation in ACD during the washout period. 20 patients were randomized into 2 groups of 10 participants. 1 dropout from the placebo group was reported
Interventions	Intervention (n = 10): oral PLC 1.5 g/d for 6 months Control (n = 10): oral placebo 1.5 g/d for 6 months
Outcomes	Initial claudication distance (PFWD) on treadmill (slope 10%, speed 2.5 km/h) Absolute claudication distance (MWD) on treadmill Ankle brachial Index
Notes	Funding by Sigma Tau
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information about sequence generation of parallel groups
Allocation concealment (selection bias)	Unclear risk	No description of method of allocation concealment
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Quote: "a controlled double‐blind trial versus placebo"
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Blinding of outcome assessment assumed, hence no influence on outcome assessment
Incomplete outcome data (attrition bias) All outcomes	Low risk	Dropout data available; all results reported in absolute and relative numbers; P values reported
Selective reporting (reporting bias)	Low risk	No selective reporting bias assumed
Other bias	Unclear risk	Small number of participants (20); possible conflict of interest (funding by Sigma Tau)