Table 2.

Univariate Analysis and Multivariable logistic regression model considering hepatocellular damage during hospital stay. Statistically significancy comparisons are highlighted in bold.

	Univariate		Multivariable
Characteristics	OR (95% CI)	p-value	OR (95% CI)	p-value
Age, median (IQR)	0.96 (0.94–0.98)	< 0.001	0.98 (0.95–1.00)	0.06
BMI, median (IQR)	0.98 (0.94–1.03)	0.44
Comorbidities
CLD, n (%)	0.64 (0.36–1.14)	0.13
CV disease, n (%)	0.37 (0.21–0.64)	< 0.001	0.70 (0.36–1.38)	0.30
Diabetes, n (%)	0.50 (0.27–0.93)	0.03	0.78 (0.39–1.59)	0.50
Hypertension, n (%)	0.57 (0.34–0.94)	0.03	0.76 (0.41–1.42)	0.39
Hospital therapy
Heparin, n (%)	3.42 (1.21–9.66)	0.02	2.28 (0.75–6.95)	0.15
Any antibiotic, n (%)	1.47 (0.40–5.36)	0.56
Penicillin, n (%)	0.84 (0.50–1.40)	0.50
Cephalosporin, n (%)	1.61 (0.87–2.96)	0.13
Carbapenem, n (%)	1.04 (0.47–2.29)	0.92
Macrolid, n (%)	2.59 (1.02–6.54)	0.05	1.95 (0.69–5.53)	0.21
Fluoroquinolone, n (%)	0.63 (0.20–1.99)	0.43
Other antibiotics, n (%)	1.04 (0.50–2.15)	0.91
Acetaminophen, n (%)	2.39 (1.32–4.34)	0.004	2.67 (1.38–5.18)	0.004
Lopinavir/ritonavir, n (%)	1.40 (0.80–2.44)	0.24
Hydroxychloquine, n (%)	1.02 (0.60–1.72)	0.94
Tocilizumab, n (%)	2.11 (0.38–11.74)	0.40
Remdesivir, n (%)	8.77 (1.96–39.30)	0.005	5.16 (1.10–24.26)	0.04
Peak laboratory test
Total bilirubin (µmol/l), median (IQR)	1.02 (1.00–1.04)	0.08
CRP (mg/l), median (IQR)	1.00 (0.99–1.00)	0.23
Ferritin (ng/ml), median (IQR)	1.00 (0.99–1.00)	0.25
INR, median (IQR)	1.68 (0.59–4.73)	0.33
D-dimer (mg/l), median (IQR)	1.03 (0.97–1.09)	0.41
paO2/FiO2, median (IQR)	1.00 (0.99–1.00)	0.41
Illness severity
Moderate ARDS	0.84 (0.44–1.61)	0.61
Severe ARDS	1.56 (0.74–3.43)	0.24

IQR interquartile range, BMI body mass index, CLD chronic liver disease, CV cardiovascular, CRP C reactive protein, INR International Normalized Ratio, paO₂ partial pressure of oxygen, FiO₂ fraction of inspired oxygen, ARDS acute respiratory distress syndrome.