Table 3.

Univariate Analysis and Multivariable logistic regression model considering death as outcome. Statistically significancy comparisons are highlighted in bold.

	Univariate		Multivariable
Characteristics	OR (95% CI)	p-value	OR (95% CI)	p-value
Gender	1.31 (0.83–2.06)	0.24
Age	1.08 (1.06–1.10)	<0.001	1.09 (1.05–1.13)	<0.001
BMI	1.00 (0.96–1.04)	0.84
Comorbidities
Number of comorbidities	1.61 (1.37–1.88)	<0.001	1.50 (0.98–2.29)	0.06
Chronic liver disease, n (%)	1.44 (0.89–2.34)	0.14
CV disease, n (%)	3.76 (2.40–5.89)	<0.001	1.26 (0.55–2.88)	0.58
Diabetes, n (%)	1.96 (1.21–3.18)	0.006	0.75 (0.31–1.82)	0.53
Hypertension, n (%)	1.58 (1.03–2.44)	0.04	0.53 (0.24–1.18)	0.12
Pulmonary disease, n (%)	1.46 (0.83–2.55)	0.19
Malignancy, n (%)	3.59 (1.98–6.50)	<0.001	2.44 (0.90–6.61)	0.08
Other comorbidities, n (%)	2.00 (1.26–3.18)	0.003
Laboratory test at admission
GGT at admission	1.00 (0.99–1.00)	0.89
ALT at admission	0.99 (0.98–1.00)	0.14
Peak GGT	1.00 (0.99–1.00)	0.17
Peak ALP	1.005 (1.001–1.008)	0.001	1.01 (1.00–1.01)	0.01
Peak ALT	0.99 (0.98–0.99)	0.004	0.99 (0.99–1.00)	0.07
Peak AST	0.99 (0.99–1.00)	0.65
Peak GGT ≥ 5X	1.38 (0.58–3.25)	0.47
Peak ALT ≥ 5X	0.52 (0.15–1.83)	0.31
Peak AST ≥ 5X	0.77 (0.25–2.40)	0.65
Peak transaminases	0.74 (0.27–2.05)	0.56
Grade ≥ 1	0.60 (0.32–1.13)	0.11
Illness gravity
Severe ARDS	2.73 (1.36–5.49)	0.005
Admission to ICU	2.99 (1.82–4.92)	<0.001	5.22 (2.28–11.90)	< 0.001

OR odds ratio, BMI body mass index, CV cardiovascular, GGT gamma-glutamyl transferase, ALT alanine aminotransferase, ALP alkaline phosphatase, AST aspartate aminotransferase, ARDS acute respiratory distress syndrome, ICU intensive care unit.