Table 2.
Univariate and multivariate Cox proportional hazards regression analysis of OS.
| Clinical characteristics | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | ||
| DDX23 expression | Low | 1 | 0.034 | 1 | 0.029 |
| High | 1.56 (1.04-2.34) | 1.58 (1.05-2.37) | |||
| Age (years) | <56 | 1 | 0.616 | ||
| ≥56 | 1.01 (0.99-1.03) | ||||
| FIGO stage (2014) | I and II | 1 | 0.010 | 1 | 0.009 |
| II and III | 1.98 (1.17-3.34) | 2.00 (1.19-3.37) | |||
| Histology | HGSOC | 1 | |||
| Non-HGSOC | 1.14 (0.53-2.47) | 0.736 | |||
| Unknown | 1.49 (0.81-2.74) | 0.196 | |||
| Grade | II (moderately) | 0.75 (0.25-2.25) | 0.609 | ||
| III (poorly) | 0.67 (0.29-1.55) | 0.349 | |||
| Unknown | 1 | ||||
| Ascites | Yes | 0.90 (0.56-1.46) | 0.681 | ||
| No | 0.46 (0.16-1.34) | 0.153 | |||
| Unknown | 1 | ||||
| CA-125 (U/mL) | <785 | 1 | 0.242 | ||
| ≥785 | 1.26 (0.86-1.86) | ||||
| Tumor diameter (cm) | <8 | 1 | 0.924 | ||
| ≥8 | 0.98 (0.65-1.49) | ||||
| Residual disease (cm) | <1 | 1 | 0.008 | ||
| ≥1 | 1.73 (1.15-2.59) | ||||
| Adjuvant chemotherapy | Yes | 0.92 (0.23-3.73) | 0.903 | ||
| No | 1 | ||||
OS, overall survival; DDX23, DEAD-Box Helicase 23; FIGO, International Federation of Gynecology and Obstetrics; CA-125, Cancer Antigen 125.