Table 1.
Subject demographics and clinical information.
| Variable | HC (n = 19) | pwMS (n = 100) | p-value | pwMS: no disability | pwMS: evidence of | p-value |
|---|---|---|---|---|---|---|
| (n = 67) | disability (n = 33) | |||||
| Age | 45 [35.55, 49.50] | 45.50 [36.75, 56] | 0.84 | 40 [35, 50] | 56 [46, 58] | 0.0001 |
| Female (%) | 11 (55) | 66 (66) | 0.49 | 46 (69%) | 20 (61%) | 0.56 |
| Disease duration | - | 11 [7,16] | - | 10 [7,15] | 13 [9,17] | 0.06 |
| EDSS | - | 1 [0, 2] | - | 0 [0, 1] | 2 [2, 3] | <2.2e-16 |
| Number of spinal cord lesions | - | 1 [0,3] | - | 1 [0,3] | 2 [0,3] | 0.46 |
| Phenotype | - | 7 CIS, 88 RRMS, 5 Progressive MS | - | 7 CIS, 60 RRMS | 28 RRMS, 5 Progressive MS | <2.2e-16 |
| Lesion volume (mm3) | - | 2,065 [717, 4,779] | - | 1,995 [734, 4,200] | 2,482 [453, 7,788] | 0.49 |
Values are presented as median [1st, 3rd quantile] for the continuous variables as the number/percent for sex and phenotype. The HC vs. pwMS as well as two disability groups of pwMS were tested for differences; p-values shown are corrected for multiple comparisons.