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. 2021 Dec 13;12:763098. doi: 10.3389/fimmu.2021.763098

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Copyright © 2021 Haslbauer, Zinner, Stalder, Schneeberger, Menter, Bassetti, Mertz, Went, Matter and Tzankov

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characteristic Gene Expression Profiling of COVID-19 Lymph Nodes. (A) Principal component analysis biplot showing distinct clustering of COVID-19 and controls in whole tissue analysis. Top up- and downregulated genes are superimposed as vectors determining the individual clusters. (B) Top 20 up-regulated genes in COVID-19 versus controls: genes related to cellular structure, motility and intracellular transport, proangiogenic and prothrombotic genes were predominantly upregulated in COVID-19. Genes involved in T-/NK- and B-cell differentiation and signaling and leukocyte trafficking were predominantly down-regulated in COVID-19.