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Effects of dantrolene (Dan) on ejection fraction following doxorubicin (Dox) treatment. Ejection fraction was measured by echocardiography in the 4 groups at 2 and 4 weeks following Dox treatment as described in Methods section. Asterisk (∗) denotes significant difference vs controls (P < .0001 at 2 weeks and P = .006 at 4 weeks) and ¥ denotes significant difference vs Dox only group (P < .0001 at 2 weeks and P = .002 at 4 weeks). N = 4–5 mice per group.
