Table 2.
Association of NLR Levels with All-Cause Mortality and Cause-Specific Mortality a
| Variable | NLR Level, Hazard Ratio (95% CI) | ||
|---|---|---|---|
| Continuous NLR | Low-NLR | High-NLR | |
| Median NLR level | 2 | 1.81 | 3.7 |
| All-cause mortality | |||
| Deaths per person-years | 4092 per 254,580 | 2581 per 209,036 | 1241 per 45,544 |
| Non-adjusted model | 1.22 (1.18, 1.26) | 1 [Reference] | 2.20 (1.83, 2.64) |
| Model 1 | 1.12 (1.08, 1.16) | 1 [Reference] | 1.53 (1.27, 1.85) |
| Model 2 | 1.12 (1.08, 1.17) | 1 [Reference] | 1.52 (1.26, 1.83) |
| Model 3 | 1.11 (1.06, 1.16) | 1 [Reference] | 1.43 (1.18, 1.73) |
| Cancer mortality | |||
| Deaths per person-years | 884 per 254,580 | 642 per 209,036 | 242 per 45,544 |
| Non-adjusted model | 1.17 (1.06, 1.29) | 1 [Reference] | 1.79 (1.20, 2.67) |
| Model 1 | 1.06 (0.95, 1.19) | 1 [Reference] | 1.30 (0.86, 1.95) |
| Model 2 | 1.07 (0.96, 1.20) | 1 [Reference] | 1.31 (0.87, 1.97) |
| Model 3 | 1.05 (0.93, 1.19) | 1 [Reference] | 1.27 (0.84, 1.92) |
| CVD mortality | |||
| Deaths per person-years | 904 per 254,580 | 622 per 209,036 | 282 per 45,544 |
| Non-adjusted model | 1.24 (1.16, 1.32) | 1 [Reference] | 2.49 (1.68, 3.70) |
| Model 1 | 1.11 (1.02, 1.21) | 1 [Reference] | 1.55 (1.04, 2.32) |
| Model 2 | 1.12 (1.03, 1.22) | 1 [Reference] | 1.56 (1.04, 2.33) |
| Model 3 | 1.09 (0.99, 1.19) | 1 [Reference] | 1.44 (0.96, 2.16) |
Notes: aAll estimates accounted for complex survey designs. Model 1 was adjusted for baseline age, sex. Model 2 was additionally adjusted for race/ethnicity, education level, marital status, family income poverty ratio level, drinking status, and smoking status. Model 3 was further adjusted for body mass index, and self-reported general health.
Abbreviations: NLR, neutrophil-lymphocyte ratio; CVD, cardiovascular disease.