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. 2021 Dec 13;12:778885. doi: 10.3389/fimmu.2021.778885

Figure 5.

Figure 5

KIR repertoire of donor and recipient NK and T cells does not influence primary graft dysfunction (PGD). (B, D) KIR2DL/S1, KIR2DL/S2/3, KIR3DL/S1 and (C, E) CD25 expression on NK and T cells was analyzed in peripheral blood of lung transplant recipients post (T0), 24 hours (T24) and three weeks after transplantation (3wk). Donor and recipient cells were distinguished by HLA mismatch using anti-HLA-A2/A1 specific Ab. Cells were gated as described in Figure 1C . DLTx recipients were divided into two groups, PGD0-1 [n = 29 for (A); n = 10 for (B–E)] and PGD2-3 [n = 10 for (A); n = 4 for (B–E)], concerning their severity of PGD at 24 hours post DLTx. (A) Frequencies of donor NK and donor T cell subsets are shown. (B, D) Illustration of frequencies of KIR positive NK and T cells and (C, E) their CD25 expression. Statistical analysis: two-way ANOVA with Sidak´s multiple comparison test and Tukey´s multiple comparison test. Data are shown as mean ± SEM, asterisks indicate p-values with *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.