Figure 2.

Neutrophil development in the bone marrow. Overview of the different neutrophil subsets in the bone marrow. Morphologically, neutrophils are divided into granulocyte-monocyte progenitor cells (GMPs), promyelocytes, myelocytes, metamyelocytes, band neutrophils, and mature neutrophils. Based on their proliferative and differentiation capacity, the cells are divided into a stem cell pool, a mitotic pool, and a post-mitotic pool. Neutrophil maturation is associated with changes in transcription factors and granule protein expression. At least four types of granules are formed in the neutrophils, each obtaining a unique set of effector molecules. The different granules are released hierarchically, opposite to their formation. Recently, single-cell sequencing or CyTOF reassessed the different neutrophil subsets and different groups have proposed a new neutrophil nomenclature.