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. 2021 Dec 13;12:718147. doi: 10.3389/fphar.2021.718147

FIGURE 15.

FIGURE 15

Neuropathological changes of cerebellar cortex (a, A, b, B) and hippocampus (c, C, d, D) in rats with the increased intra-abdominal pressure at 25 mmHg for 60 min (a, A, c, C) or at 50 mmHg for 25 min (b, B, d, D), treated at 10 min increased intra-abdominal pressure time with saline (control, a, b, c, d) or BPC 157 (A, B, C, D). Control rats exhibited within cerebellar area karyopyknosis and degeneration of Purkinje cells (a, b). Marked and progressive karyopyknosis and degeneration of pyramidal cell of the hippocampus was observed in control rats (arrows) at 25 mmHg intraabdominal pressure (c) and even more at 50 mmHg intra-abdominal pressure (d). No change was found in the cerebellar and hippocampal area in BPC 157- treated rats at 25 mmHg intra-abdominal pressure (A, B, C) and only rare hippocampal karyopyknotic cells (arrows) at 50 mmHg intra-abdominal pressure (D) (HE; magnification ×400, scale bar 50 μm).