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. 2021 Dec 13;8:761841. doi: 10.3389/fmolb.2021.761841

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Copyright © 2021 Hu, Zhang, Li, Liu, Ao, Li, Zeng and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ATF3 facilitating pro-inflammatory cytokine secretion in rheumatoid arthritis fibroblast-like synoviocyte (RA-FLS) and MH7A. (A and C) ELISA assays showed that IL-1β, IL-6, and IL-8 in the Sh-ATF3 group were lower than those in the Sh-Ctrl group with or without TNF-α stimulation, which in the ATF3-OE group were higher than those in the Ctrl-OE group (mean ± SD, n = 3). (B and D) Similarly, qRT-PCR assays revealed that IL-1β, IL-6, and IL-8 in the Sh-ATF3 group were lower than those in the Sh-Ctrl group with or without TNF-α stimulation, which in the ATF3-OE group were higher than those in the Ctrl-OE group (mean ± SD, n = 3). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.