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. 2021 Dec 13;8:761841. doi: 10.3389/fmolb.2021.761841

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Copyright © 2021 Hu, Zhang, Li, Liu, Ao, Li, Zeng and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene Set Enrichment Analysis shows that pathways enriched in the high ATF3 group were associated with metabolism in the GPL570 and GPL96 databases (A and C), while the inflammation- and immunoregulation-associated pathways were enriched in the low ATF3 group in the GPL570 and GPL96 databases (B and D). (E and F) The relative percentage of different infiltrated immune cells in rheumatoid arthritis (RA) samples in the GPL570 and GPL96 databases. (G and H) The immune cell correlation matrix was constructed to explore the correlation among all infiltrated immune cells in the GPL570 and GPL96 databases. (I and J) The infiltrated immune cells between the high and low ATF3 groups were compared in the GPL570 and GPL96 databases, and the contents of activated mast cells in the high ATF3 group were widely and significantly higher than those in the low ATF3 group in both databases. * p < 0.05.