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. 2021 Dec 13;8:761841. doi: 10.3389/fmolb.2021.761841

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Copyright © 2021 Hu, Zhang, Li, Liu, Ao, Li, Zeng and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ATF3 could promote cell migration and invasion in rheumatoid arthritis fibroblast-like synoviocyte (RA-FLS) and MH7A. (A) The mRNA of knockdown and overexpressed ATF3 was verified by qRT-PCR (mean ± SD, n = 3). (B) Transwell assay indicated that ATF3 silence decreased the ability of cell migration and invasion, while ATF3 overexpression significantly promoted cell migration and invasion in RA-FLS and MH7A. t-Test was used to analyze the statistical difference. **** p < 0.0001.